Domperidone has, on rare occasions, been associated with acute extrapyramidal syndromes, especially in young children, but, to our knowledge, this is the first case of domperidone-induced tardive dyskinesia and withdrawal psychosis, adverse effects associated with chronic central nervous system dopaminergic blockade. Domperidone is a dopamine D₂ receptor antagonist that does not usually. Some of the mothers in our clinic, breastfeeding adopted babies, have been on the medication for 18 months without any apparent side effects. As mentioned in the information sheet Domperidone, Getting Started, patients using domperidone for stomach disorders may be on it for many years. We hope you won’t need domperidone for very long, but if it’s necessary and helpful, stay on it. Side Effects. Drug information provided by: IBM Micromedex. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Stopping Domperidone How long can I use domperidone? When domperidone was being used for babies (and now that cisapride is off the market, it is being used again), it was common for the babies to be on the medication for several months, even longer. Domperidone – Information for Breastfeeding Parents Domperidone (Motilium) is a drug that, as a side effect, increases breastmilk production by increasing prolactin (a hormone involved in making milk) secretion from the pituitary gland. What form(s) does this medication come in? Each white, plain-coated, round, biconvex tablet, engraved with rph D51 on one side and plain on the other, contains domperidone maleate 12.72 mg (equivalent to domperidone 10 mg). Domperidone, Stopping. When domperidone was being used for babies (and now that cisapride is off the market, it is being used again), it was common for the babies to be on the medication for several months, even longer. Introduction. Domperidone is a peripheral dopamine D 2-receptor antagonist with both gastrokinetic and antiemetic activity via its inhibitory effects on dopamine receptors in gastrointestinal smooth muscle and the chemoreceptor trigger zone. 1 Health Canada–approved indications include the management of symptoms associated with upper. Stopping the Domperidone. Although most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother’s milk supply to adjust without frustrating the baby or causing her discomfort. How to take domperidone. Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about domperidone and will provide you with a full list of the side-effects which you may experience from taking it.